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Similarly, in an adjusted Cox regression model, individuals in the AG and AA genotype groups were at significantly increased risk of vitamin B 12 deficiency compared with individuals in the reference GG genotype group (additive model

doi:10.1371/journal.pone.0226626 Cho HK, Kim S, Lee EJ, Kee C

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This genetic defect is more common in South Asians and those of African origin, and unlike transcobalmin deficiency, is associated with other B12 biomarkers in the normal range and no clinical symptoms